Senior Medical Director at Enigma Search in South San Francisco, California, United States
- Company: Enigma Search
- Location: South San Francisco, California, United States
- Posted: Sep 20, 2026
- Type: Full-time
- Experience: 5+ years
Overview
Our client is seeking a Medical Director or Senior Medical Director to lead their Neurological and Neuropsychiatric clinical portfolio. This is a high-impact role reporting directly to the Head of Clinical Sciences. You will be the clinical architect for programs moving from preclinical discovery in…
Job description
- Our client is seeking a Medical Director or Senior Medical Director to lead their Neurological and Neuropsychiatric clinical portfolio.
- This is a high-impact role reporting directly to the Head of Clinical Sciences. You will be the clinical architect for programs moving from preclinical discovery into human "Proof-of-Mechanism" and "Proof-of-Concept" trials.
- This is not a traditional "late-stage" medical monitoring role. This is a position for a scientist-clinician who wants to be at the forefront of Early Development (Translational), working on novel targets that have the potential to redefine how we treat neurological diseases.
Responsibilities
- Strategic Leadership: Lead high-performing cross-functional teams to translate preclinical data into robust human clinical strategies and biomarker development.
- Experimental Medicine: Design and execute innovative "Phase 0" through Phase 2 studies to demonstrate proof-of-mechanism for novel targets in the neuropsychiatric space.
- Collaborative Discovery: Act as a key interface between research and drug development, working closely with discovery scientists and external partners to shape disease indication strategies.
- Clinical Expertise: Utilize your medical background to guide the development of preclinical models and ensure they align with human clinical needs.
- Regulatory & Scientific Content: Author and provide expert medical oversight for protocols, Investigator Brochures (IBs), Clinical Study Reports (CSRs), and regulatory submissions.
Requirements
- Physician-Scientist: You hold an M.D. or an M.D./Ph.D. with a deep scientific mindset.
- Neurology Expert: Board certification or eligibility in Neurology or Pediatric Neurology is highly preferred.
- Proven Industry Veteran: You have 5+ years of translational or clinical drug development experience within biotech, pharma, or a top-tier academic research setting.
- Early Phase Specialist: You possess direct experience or a deep working knowledge of early clinical trial methodology (Phase 0, 1, and 2).
- Collaborative Leader: You excel in a matrixed environment, possessing the ability to lead through influence and bring out the best in cross-functional teams.
Skills
Required
- M.D. or M.D./Ph.D.