Senior Clinical Trial Manager (Contract) at Centessa Pharmaceuticals, LLC in Boston, MA

Job description

• Centessa is seeking a (contract-to-hire) Senior Clinical Trial Manager (Sr. CTM) to lead the execution of global clinical studies from startup through closeout and clinical study report. This role is a temporary position with the potential to convert to a permanent role, accountable for study delivery, including operational strategy, timelines, budget, quality, vendor oversight, risk management, and inspection readiness. This individual in this role will lead cross-functional teams and manage CROs and external vendors to ensure studies are conducted efficiently, compliantly, and in alignment with program objectives.

Responsibilities

• Lead the planning, execution, and oversight of global clinical trials from startup through closeout.
• Serve as the primary operational lead for assigned studies, driving cross-functional alignment and execution.
• Develop and manage study timelines, budgets, enrollment forecasts, risk mitigation plans, and key performance metrics.
• Oversee CROs and external vendors to ensure delivery against scope, quality standards, timelines, and budget.
• Drive critical study milestones, including site activation, enrollment, database lock, and study closeout.
• Review and approve study plans, vendor deliverables, and trial documentation to ensure compliance with protocol, GCP, and regulatory requirements.
• Identify operational risks and issues, implement mitigation strategies, and escalate as appropriate.
• Lead study team meetings and provide regular updates to stakeholders and senior management.
• Ensure Trial Master File (TMF) quality, completeness, and inspection readiness throughout the study lifecycle.
• Support regulatory submissions, audits, inspections, and Health Authority interactions.
• Contribute to process improvements and mentor junior clinical operations team members as needed.
• Collaborate effectively with global teams, investigators, CROs, and vendors across multiple regions.

Requirements

• Bachelor's degree in a scientific, health-related, or equivalent discipline required.
• 8+ years of clinical research experience, including 5+ years of clinical trial management experience within a sponsor or CRO environment.  2+ years of managing Phase 1 Healthy Volunteer studies.
• Experience in standard clinical pharmacology package studies such as: First in Human, Drug to Drug Interaction, Human Absorption, Metabolism, Excretion and Mass Balance, Relative Bioavailability, Bioequivalence, Organ Impairment, Abuse Liability studies.
• Demonstrated experience independently leading Phase 1 studies, global Phase II and/or Phase III clinical trials.
• Experience managing CROs, CRUs, central vendors, and cross-functional study teams.
• Neuroscience/CNS clinical development experience preferred.
• Experience supporting inspection readiness, audits, and regulatory interactions preferred.

Skills

Required

• Clinical trial management
• Vendor oversight
• CRO management
• Risk management
• Regulatory compliance
• GCP
• Trial Master File (TMF) management
• Inspection readiness
• Cross-functional team leadership
• Budget management
• Timeline management

Preferred

• Neuroscience/CNS clinical development

Benefits

• The hourly range for this position is $70.00 to $100.00 per hour. Individual compensation within this range will be determined based on a variety of factors, including qualifications, skills, relevant experience, and job knowledge.
• Contractors engaged through Centessa are employed through a third-party agency that serves as the employer of record and provides access to a comprehensive benefits package. Eligible contractors may enroll in medical plans, including PPO and EPO options, as well as dental and vision coverage after 30 days. Additional perks, such as a 401(k), wellness programs, and other discounts, may also be available to eligible contractors.