Clinical Trial Manager at Enigma Search in South San Francisco, California, United States
- Company: Enigma Search
- Location: South San Francisco, California, United States
- Posted: Sep 18, 2026
- Type: Full-time
- Experience: 4+ years
Overview
This is an opportunity to join a science-driven organization focused on advancing precision medicine for patients with both common and rare diseases. The Clinical Trial Manager (CTM) will play a key, hands-on role in supporting the execution of clinical programs in Chronic Kidney Disease (CKD).
Job description
- This is an opportunity to join a science-driven organization focused on advancing precision medicine for patients with both common and rare diseases. The Clinical Trial Manager (CTM) will play a key, hands-on role in supporting the execution of clinical programs in Chronic Kidney Disease (CKD).
- In this position, you will contribute to mid- to late-stage clinical studies, working cross-functionally with internal stakeholders and external partners to ensure studies are executed efficiently, on time, and in compliance with quality and regulatory standards. This role is well-suited for someone who enjoys being deeply involved in trial execution, collaborating across functions, and helping bring innovative therapies to patients.
Responsibilities
- Lead or co-lead the execution of one or more Phase 2 clinical trials in CKD, overseeing activities from protocol development through key milestones such as first patient in (FPI), interim analysis, database lock, and clinical study report completion.
- Oversee and manage external partners, including CROs, vendors, and global clinical sites.
- Ensure study conduct aligns with protocols, SOPs, and regulatory requirements, including ICH-GCP, through oversight of site monitoring and trial activities.
- Support the development and review of key study documents, including CRFs, informed consent forms (ICFs), and patient-facing materials.
- Represent Clinical Operations on cross-functional teams, including participation in Study Execution Team (SET) meetings.
- Collaborate with Clinical Operations and Clinical Science to support engagement with key opinion leaders (KOLs) and investigators.
Requirements
- Bachelor's degree or higher in a scientific or healthcare-related field.
- At least 4 years of clinical research experience, including a minimum of 2 years in a Clinical Trial Manager role within a biotech, pharma company, or CRO environment.
- Experience supporting early to mid-stage clinical trials (Phase I–II preferred).
- Demonstrated ability to manage clinical trials from study start-up through close-out.
- Working knowledge of FDA regulations and ICH-GCP guidelines.